Nasopharyngeal Synovial Sarcoma - An Oncological Surprise

Ram Abhinav Kannan, Kirthi Koushik, Nalini Kilara, Aparna Gangoli

Abstract


Synovial sarcoma is a rare and aggressive high-grade neoplasm with poor prognosis. It is usually encountered in the lower extremities of young adults; only a few cases have been reported in the head and neck region. We report the fourth case of synovial sarcoma of the nasopharynx, treated with neoadjuvant chemotherapy, complete surgical excision and adjuvant radiation with extensive review of literature.


Keywords


Synovial Sarcoma; Nasopharynx; Surgery; Radiation; Neoadjuvant Chemotherapy

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References


Trassard M, Le Doussal V, Hacène K, et al. Prognostic factors in localized primary synovial sarcoma: a multicenter study of 128 adult patients. J Clin Oncol 2001; 19:525-34.

Ferrari A, Gronchi A, Casanova M, et al. Synovial sarcoma: a retrospective analysis of 271 patients of all ages treated at a single institution. Cancer 2004; 101:627-34.

Harb WJ, Luna MA, Patel SR, et al. Survival in patients with synovial sarcoma of the head and neck: association with tumor location, size, and extension. Head Neck 2007; 29:731-40.

Verma A, Mehta S, Mann SBS, Radotra BD. Synovial sarcoma of the nasopharynx. Ear Nose Throat J 2002; 81:36-9.

Lin HC, Friedman M, Kuo FY, Huang HY. Synovial sarcoma of the Eustachian tube. Head Neck 2009; 31:1245-8.

Nakahira M, Sugasawa M, Morita K. Monophasic synovial sarcoma of the nasopharynx. Auris Nasus Larynx 2013; 40: 413-6.

Wenig BM. Atlas of head and neck pathology. Philadelphia, PA: Saunders-Elsevier 2008; 514-21.

Limon J, Mrozek K, Mandant N, et al. Cytogenetics of synovial sarcoma: presentation of ten new cases and review of the literature. Genes Chromosomes Cancer 1991; 3: 338-45.

Roth JA, Enzinger FM, Tannenbaum M. Synovial sarcoma of the neck: a follow-up study of 24 cases. Cancer 1975; 35:1243-53.

Bukachevsky RP, Pincus RL, Shechtman FG, et al. Synovial sarcoma of the head and neck. Head Neck 1992; 14:44-8.

Nadig SK, Love MHS, Brooker DS, Hall SJ. Synovial sarcoma in the retropharyngeal space. J Laryngol Otol 2002; 116:224-6.

Lenoir P, Ramet J, Goossens A, et al. Retropharyngeal synovial sarcoma in an infant: Report of a case and of its response to chemotherapy; review of the literature. Pediatr Hernatol Oncol 1991:8:45-52.

Amble FR, Olsen KD, Nascimento AG, Foote RL. Head and neck synovial cell sarcoma. Otolaryngol Head Neck Surg 1992; 107:631-7.

Giaoui L, Salvan D, Casiraghi O, et al. Primary synovial sarcoma of the head and neck. Materials of The Gustave Roussy Institute. Report of 13 cases. Ann Otolaryngol Chir Cervicofac 1999; 116:71-7.

Thompson RC Jr, Garg A, Goswitz J, et al. Synovial sarcoma. Large size predicts poor outcome. Clin Orthop Relat Res 2000; 373:18-24.

Yokoyama K, Shinohara N, Kondo M, Mashima T. Prognostic factors in synovial sarcoma: A clinicopathologic study of 18 cases. Jpn J Clin Oncol 1995; 25:131-4.

El-Nagger AK, Ayala AG, Abdulkarim FW, et al. Synovial sarcoma. A DNA flow cytometric study. Cancer 1990; 65:2295-300.

Milchgrub S, Ghandur-Mnaymneh I, Dorfman HD, Albores- Saarendra J. Synovial sarcoma with extensive osteoid and bone formation. Am J Surg Pathol 1993; 17:357-63.




DOI: http://dx.doi.org/10.14319/ijcto.0204.12

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