Monte Carlo study of secondary electron production from gold nanoparticle in proton beam irradiation
Purpose: In this study, we examined some characteristics of secondary electrons produced by gold nanoparticle (NP) during proton beam irradiation.
Method: By using the Geant4 Monte Carlo simulation toolkit, we simulated the NP at the range from radius (r) of 17.5 nm, 25 nm, 35 nm to r = 50 nm. The proton beam energies used were 20MeV, 50MeV, and 100MeV. Findings on secondary electron production and their average kinetic energy are presented in this paper.
Results: Firstly, for NP with a finite size, the secondary electron production increase with decreasing incident proton beam energy and secondary buildup existed outside NP. Secondly, the average kinetic energy of secondary electrons produced by a gold NP increased with incident proton beam energy. Thirdly, the larger the NP size, the more the secondary electron production.
Conclusion: Collectively, our results suggest that apart from biological uptake efficiency, we should take the secondary electron production effect into account when considering the potential use of NPs in proton beam irradiation.
Cite this article as: Gao J, Zheng Y. Monte Carlo study of secondary electron production from gold nanoparticle in proton beam irradiation. Int J Cancer Ther Oncol 2014; 2(2):02025.
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