Relapse of unusual localization of classic seminoma with post-chemotherapy transformation
Germ cell tumor is the most common cancer among males in the 20–39 year-old age range, representing 21% of invasive cancer diagnose. The vast majority of testicular tumors in this age range are germ cell tumors. There are two types of malignant tumors, the pure seminoma cell and non-seminomatous germinal cell tumors (NGCT). We present the case of a patient who underwent a testicular tumor surgery, classic seminoma stage I, receiving two cycles of adjuvant carboplatin chemotherapy. During the follow up, an elevation on the alpha-fetoprotein level was observed, thus the final diagnosis was adenopatic recurrence of the Yolk Sac tumor.
Cite this article as: Urena MD, Legeren M, Galvez F, Villaescusa A, Aparicio J, Jurado JM, Blancas I, Sanchez MJ, Romera AL, Martinez AP, Quiñonez E, Dulcey I, Puche JL. Relapse of unusual localization of classic seminoma with post-chemotherapy transformation. Int J Cancer Ther Oncol 2014; 2(1):02016.
Hayes-Lattin B, Nichols CR. Testicular cancer: a prototypic tumor of young adults. Semin Oncol 2009; 36: 432-8.
Bower M, Rustin GJ. Serum tumor markers and their role in monitoring germ cell cancers of the testis. In: Textbook of Genitourinary Oncology, 2nd, Vogelzang NJ, Scardino PT, Shipley,WU, Coffey, DS (Eds), Lippincott, Williams and Wilkins, Philadelphia 2000 p931.
Fossa A, Fossa SD. Serum lactate dehydrogenase and human choriogonadotrophin in seminoma. Br J Urol 1989; 63:408.
Warde P, Gospodarowicz M. Evolving concepts in stage I seminoma. BJU Int 2009; 104:1357-61.
Von der Maase H, Specht L, Jacobsen GK, et al. Surveillance following orchiectomy for stage I seminoma of testis. Eur J Cancer 1993; 29A: 1931-4.
Germa-Lluch JR, Climent MA, Villavicencio H, et al. Treatment of stage I testicular tumours. Br J Urol 1993; 71: 473-7.
Srigley JR, Mackay B, Toth P, et al. The ultrastructure and histogenesis of male germ neoplasia with emphasis on seminoma with early carcinomatous features. Ultrastruct Pathol 1988; 12: 67-86.
Czaja JT, Ulbright TM. Evidence for the transformation of seminoma to yolk sac tumor, with histogenetic considerations. Am J Clin Pathol 1992; 97: 468-77.
Parkash V, Carcangiu ML. Transformation of ovarian dysgerminoma to yolk sac tumor: evidence for a histogenetic continuum. Mod Pathol 1995; 8: 881-7.
This work is licensed under a Creative Commons Attribution 3.0 License.
International Journal of Cancer Therapy and Oncology (ISSN 2330-4049)
© International Journal of Cancer Therapy and Oncology (IJCTO)
To make sure that you can receive messages from us, please add the 'ijcto.org' domain to your e-mail 'safe list'. If you do not receive e-mail in your 'inbox', check your 'bulk mail' or 'junk mail' folders.