Radiation protection and secondary cancer prevention using biological radioprotectors in radiotherapy

Hamid Abdollahi, Isaac Shiri, Mohammadreza Atashzar, Maghsoud Sarebani, Kave Moloudi, Hadi Samadian


Radiotherapy is the feasible treatment approach for many malignant diseases and cancers. New radiotherapy techniques such as ion therapy, stereotactic radiosurgery and intensity modulated radiation therapy deliver higher low dose radiation to large volume of normal tissues and are in debating as more secondary cancers inducers. A secondary cancer after radiotherapy is an important issue that reduces treatment efficiency and should be decreased. Radioprotective compounds are of importance in clinical radiation therapy for saving normal tissues. In the present study, we are so interest to introduce, suggest and review the application of biological radioprotectors in radiotherapy. We propose probiotics, prebiotics, gas, vitamin and nanoparticle producing microorganisms as new biological systems based radioprotectors to protect normal tissues. Also, we reviewed the main biological pathways, molecules and also radioadaptive response that act as radioprotectors. In this review we tried to address the secondary cancer induction by radiotherapy and also main biological radiation protection approaches, although there is a wealth of data in this subject.  


Secondary Cancer; Prevention; Radiotherapy; Biological Radioprotectors

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DOI: http://dx.doi.org/10.14319/ijcto.33.5

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