Antineoplastic mechanisms of Iodine in cancers that take up Iodine

Abstract

Purpose: In addition to being a component of thyroid hormone (TH), iodine can be an antioxidant as well as an antiproliferative and differentiation agent that helps to maintain the integrity of several organs with the ability to take up iodine.

Methods and Results: Studies from our laboratory shown that in preclinical (cell culture, induced animal cancer and xenographs) and clinical studies (mammary cancer protocol), molecular iodine (I₂) supplementation exerts suppressive effects on implantation, development, and progression of cancer neoplasias. These effects can be mediated by a variety of mechanisms and pathways, including direct actions, in which the oxidized iodine modulates the immune/tumor response and through iodolipid formation and the activation of peroxisome proliferator-activated receptors type gamma (PPARγ) triggering apoptotic and/or differentiation pathways.

Conclusion: The absence of side effects and the easy availability and handling of I₂ have allowed the establishment of clinical protocols to utilize I₂ supplementation as an adjuvant in therapies against cancers that take up iodine.

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Cite this article as:  Aceves C, Anguiano B. Antineoplastic mechanisms of Iodine in cancers that take up Iodine. Int J Cancer Ther Oncol 2015; 3(4):3401.

[This abstract was presented at the BIT’s 8^th Annual World Cancer Congress, which was held from May 15-17, 2015 in Beijing, China.]