Imatinib in PDGFR positive malignant solitary fibrous tumour of the pleura

Sarah Bigeni, Cynthia Jones, Joseph Galea

Abstract


In 2013, two cases of malignant solitary fibrous tumours (MSFTs) were diagnosed in Malta. Both were inoperable at presentation. Both tumours expressed platelet-derived growth factor receptor (PDGFR) with no mutations and the tyrosine kinase inhibitor imatinib was prescribed. Nonetheless, treatment was not as effective as documented in previous case-reports.

Keywords


Malignant Solitary Fibrous Tumours, Imatinib, Pleura, PDGFR

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References


Santambrogio L, Nosotti M, Palleschi A, et al. Solitary fibrous tumor of the pleura presenting with syncope episodes when coughing. World J Surg Oncol. 2008;6:86.

Hanau CA, Miettinen M. Solitary fibrous tumour: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol. 1995; 26(4):440-9.

de Perrot M, Fischer S, Brundler MA, et al. Solitary fibrous tumours of the pleura. Ann Thorac Surg. 2002; 74(1):285-93.

Kim HJ, Lee HK, Seo JJ, et al. MR imaging of solitary fibrous tumours in the head and neck. Korean J Radiol 2005;6(3):136-42.

Robinson LA. Solitary fibrous tumour of the pleura. Cancer Control. 2006;13(4):264-9.

De Pas T, Toffalorio F, Colombo P, et al. Brief report: activity of imatinib in a patient with platelet-derived-growth-factor receptor positive malignant solitary fibrous tumour of the pleura. J Thorac Oncol. 2008;3(8):938-41.

Park MS, Ravi V, Conley A, et al. The role of chemotherapy in advanced solitary fibrous tumours; a retrospective analysis. Clin Sarcoma Res. 2013;3(1):7.

Constantinidou A, Jones RL, Scurr M, et al. Systemic therapy in solitary fibrous tumour. Proceedings of the 15th Connective Tissue Oncologic Society Annual Meeting. Miami, Florida, USA; 2009.

Corless CL, Schroeder A, Griffith D, et al. PDGFRA mutations in gastrointestinal stromal tumours: frequency, spectrum and in vitro sensitivity to imatinib. J Clin Oncol. 2005;23(23):5357-64.

Stacchiotti S, Negri T, Palassini E, et al. Sunitinib malate and figitumumab in solitary fibrous tumor: patterns and molecular bases of tumor response. Mol Cancer Ther. 2010; 9(5):1286-97.

Park MS, Patel SR, Ludwig JA, et al. Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumour. Cancer. 2011;117(21):4939-47.




DOI: http://dx.doi.org/10.14319/ijcto.41.16

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International Journal of Cancer Therapy and Oncology (ISSN 2330-4049)

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